Carvedilol
Blood pressure medication / From Wikipedia, the free encyclopedia
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Carvedilol, sold under the brand name Coreg among others, is a medication used to treat high blood pressure, congestive heart failure (CHF), and left ventricular dysfunction in people who are otherwise stable.[1] For high blood pressure, it is generally a second-line treatment.[1] It is taken by mouth.[1]
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Trade names | Coreg, others |
Other names | BM-14190 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697042 |
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Routes of administration | By mouth |
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Bioavailability | 25–35% |
Protein binding | 98% |
Metabolism | Liver (CYP2D6, CYP2C9) |
Elimination half-life | 7–10 hours |
Excretion | Urine (16%), feces (60%) |
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ECHA InfoCard | 100.117.236 |
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Formula | C24H26N2O4 |
Molar mass | 406.482 g·mol−1 |
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Chirality | Racemic mixture |
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Common side effects include dizziness, tiredness, joint pain, low blood pressure, nausea, and shortness of breath.[1] Severe side effects may include bronchospasm.[1] Safety during pregnancy or breastfeeding is unclear.[2] Use is not recommended in those with liver problems.[3] Carvedilol is a nonselective beta blocker and alpha-1 blocker.[1] How it improves outcomes is not entirely clear but may involve dilation of blood vessels.[1]
Carvedilol was patented in 1978 and approved for medical use in the United States in 1995.[1][4] It is on the World Health Organization's List of Essential Medicines.[5] It is available as a generic medication.[1] In 2021, it was the 26th most commonly prescribed medication in the United States, with more than 21 million prescriptions.[6][7]