Central nervous system fatigue
Associated with concentration changes in synaptic neurotransmitters in the CNS / From Wikipedia, the free encyclopedia
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Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.[1][2][3][4] In healthy individuals, central fatigue can occur from prolonged exercise and is associated with neurochemical changes in the brain, involving (but not limited to) serotonin (5-HT), noradrenaline, and dopamine.[2][3][4] The roles of dopamine, noradrenaline, and serotonin in CNS fatigue are unclear, as pharmacological manipulation of these systems has yielded mixed results.[5][6] Central fatigue plays an important role in endurance sports and also highlights the importance of proper nutrition in endurance athletes.