Cinnarizine
Antihistamine and calcium channel blocker medication / From Wikipedia, the free encyclopedia
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Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group.[5] It is prescribed for nausea and vomiting due to motion sickness[6] or other sources such as chemotherapy,[7] vertigo,[8] or Ménière's disease.[9]
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Trade names | Stugeron, Stunarone, Cinarin |
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Routes of administration | Oral |
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Bioavailability | Low[1] |
Metabolism | Entire[2][3] |
Elimination half-life | 3–4 hours[4] |
Excretion | 1⁄3 urine, 2⁄3 faeces[2] |
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ECHA InfoCard | 100.005.514 |
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Formula | C26H28N2 |
Molar mass | 368.524 g·mol−1 |
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Cinnarizine was first synthesized as R1575 by Janssen Pharmaceutica in 1955. The nonproprietary name is derived from the cinnamyl substituent on one of the nitrogen atoms, combined with the generic ending "-rizine" for "antihistaminics/cerebral (or peripheral) vasodilators".[10] It is not available in the United States or Canada. It has also been cited as one of the most used drugs for seasickness within the British Royal Navy.[11]