Dengue vaccine
Vaccine against dengue fever / From Wikipedia, the free encyclopedia
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Dengue vaccine is a vaccine used to prevent dengue fever in humans.[9] Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes.[10] As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga.[11][12]
Vaccine description | |
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Target | Dengue fever |
Vaccine type | Attenuated |
Clinical data | |
Trade names | Dengvaxia, Qdenga |
Other names | CYD-TDV |
AHFS/Drugs.com | Monograph |
License data | |
Routes of administration | Subcutaneous |
ATC code | |
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CAS Number | |
DrugBank | |
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Dengvaxia is only recommended in those who have previously had dengue fever or populations in which most people have been previously infected due to phenomenon known as antibody-dependent enhancement.[13] The value of Dengavaxia is limited by the fact that it may increase the risk of severe dengue in those who have not previously been infected.[14][13] In 2017, more than 733,000 children and more than 50,000 adult volunteers were vaccinated with Dengvaxia regardless of serostatus, which led to a controversy.[15] Qdenga is designated for people not previously infected.[16]
There are other vaccine candidates in development including live attenuated, inactivated, DNA and subunit vaccines.[10]