Diphenoxylate
Centrally active opioid drug used for the treatment of diarrhea / From Wikipedia, the free encyclopedia
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Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridium difficile infection.
Quick Facts Clinical data, Other names ...
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Other names | R-1132, NIH-756 |
AHFS/Drugs.com | Monograph |
Routes of administration | Oral |
Drug class | Opioid Antidiarrheal |
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Protein binding | 74–95% |
Elimination half-life | 12–14 hours |
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ECHA InfoCard | 100.011.837 |
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Formula | C30H32N2O2 |
Molar mass | 452.598 g·mol−1 |
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