Disopyramide
Chemical compound / From Wikipedia, the free encyclopedia
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Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia.[2] It is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent.[3][4] Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility.[5][6] Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms. In 1972, when it was one of the only alternatives to quinidine, it was praised for being more potent and somewhat less toxic.[6] However, a 2012 review of antiarrhythmic drugs noted that disopyramide is among the most toxic agents, with a high burden of side effects and increased mortality (compared to placebo) when used to treat atrial fibrillation.[7]
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Trade names | Norpace |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682408 |
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Routes of administration | Oral, intravenous |
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Bioavailability | High |
Protein binding | 50% to 65% (concentration-dependent) |
Metabolism | Hepatic (CYP3A4-mediated) |
Elimination half-life | 6.7 hours (range 4 to 10 hours) |
Excretion | Renal (80%) |
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ECHA InfoCard | 100.021.010 |
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Formula | C21H29N3O |
Molar mass | 339.483 g·mol−1 |
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Melting point | 94.5 to 95 °C (202.1 to 203.0 °F) |
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