Dosulepin
Antidepressant / From Wikipedia, the free encyclopedia
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Not to be confused with Doxepin.
Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.[4][6][7] Dosulepin was once the most frequently prescribed antidepressant in the United Kingdom, but it is no longer widely used due to its relatively high toxicity in overdose without therapeutic advantages over other TCAs.[6][8][9] It acts as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.[4][10][11]
Quick Facts Clinical data, Trade names ...
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Trade names | Prothiaden, others |
Other names | IZ-914, KS-1596[1][2][3], dothiepin (USAN US) |
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Routes of administration | Oral |
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Bioavailability | 30%[4] |
Protein binding | 84%[5] |
Metabolism | Hepatic (N-demethylation, S-oxidation, glucuronidation)[5] |
Metabolites | Northiaden, dothiepin sulfoxide, northiaden sulfoxide, glucuronide conjugates[4] |
Elimination half-life | Dothiepin: 14.4–23.9 hours[4] Dothiepin sulfoxide: 22.7–25.5 hours[4] Northiaden: 34.7–45.7 hours[4] Northiaden sulfoxide: 24.2–33.5 hours[4] |
Excretion | Urine: 56%[4] Feces: 15%[4] |
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ECHA InfoCard | 100.003.665 |
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Formula | C19H21NS |
Molar mass | 295.44 g·mol−1 |
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