Estradiol dienantate
Chemical compound / From Wikipedia, the free encyclopedia
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Estradiol dienanthate (EDE), sold under the brand names Climacteron among others, is a long-acting estrogen medication which was previously used in menopausal hormone therapy for women and to suppress lactation in women.[1][2][3][4] It was formulated in combination with estradiol benzoate (EB), a short-acting estrogen, and testosterone enanthate benzilic acid hydrazone (TEBH), a long-acting androgen/anabolic steroid.[2][3][4] EDE has not been made available for medical use alone.[5] The medication, in combination with EB and TEBH, was given by injection into muscle once or at regular intervals, for instance once every 6 weeks.[6][7][8]
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Trade names | Climacteron, Amenose, Lactimex, Lactostat (all combinations) |
Other names | Estradiol dienantate; EDE; EDEn; E2-EDN; Estradiol diheptanoate; Estra-1,3,5(10)-triene-3,17β-diol 3,17β-diheptanoate |
Routes of administration | Intramuscular injection |
Drug class | Estrogen; Estrogen ester |
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ECHA InfoCard | 100.028.903 |
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Formula | C32H48O4 |
Molar mass | 496.732 g·mol−1 |
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Side effects of EDE include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[9] EDE is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.[10][11] It is an estrogen ester and a prodrug of estradiol in the body.[11][10] Because of this, it is considered to be a natural and bioidentical form of estrogen.[11]
EDE was first described by 1959.[12][13] It was previously available in Canada and Germany but was discontinued by 2005.[14][15][16] The medication is no longer available in any form.[5]