Flurazepam
Hypnotic medication / From Wikipedia, the free encyclopedia
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Flurazepam[2] (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite with a long half-life, which may stay in the bloodstream for days.[3] Flurazepam was patented in 1968 and came into medical use the same year.[4] Flurazepam, developed by Roche Pharmaceuticals, was one of the first benzodiazepine hypnotic medications to be marketed.[5]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Dalmane, Dalmadorm, Fluzepam |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682051 |
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Addiction liability | Moderate |
Routes of administration | By mouth |
Drug class | Benzodiazepine |
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Pharmacokinetic data | |
Bioavailability | 83% |
Metabolism | Liver |
Metabolites | N-desalkylflurazepam (active metabolite) |
Elimination half-life | 2.3 hours N-desalkylflurazepam: 47–100 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.037.795 |
Chemical and physical data | |
Formula | C21H23ClFN3O |
Molar mass | 387.88 g·mol−1 |
3D model (JSmol) | |
Melting point | 79.5 °C (175.1 °F) |
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