Flurbiprofen
Chemical compound / From Wikipedia, the free encyclopedia
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Flurbiprofen is a member of the phenylalkanoic acid derivative family of nonsteroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.[2]
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Trade names | Ansaid, Ocufen, Strepfen |
Other names | (±)-2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid |
AHFS/Drugs.com | Monograph |
MedlinePlus | a687005 |
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Routes of administration | By mouth |
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Protein binding | > 99% |
Metabolism | Liver (CYP2C9) |
Elimination half-life | 4.7-5.7 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.023.479 |
Chemical and physical data | |
Formula | C15H13FO2 |
Molar mass | 244.265 g·mol−1 |
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Chirality | Racemic mixture |
Melting point | 117 °C (243 °F) |
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It was derived from propionic acid by the research arm of Boots UK during the 1960s, a period which also included the discovery of ibuprofen, indometacin, diclofenac, naproxen, ketoprofen, and sulindac.[3][4]: 34
It was patented in 1964 by Boots UK and approved for medical use in 1987.[5] It was approved in the US in 1988; the first generic was approved in 1994.[6]: 158