Frontostriatal circuit
From Wikipedia, the free encyclopedia
Frontostriatal circuits are neural pathways that connect frontal lobe regions with the striatum and mediate motor, cognitive, and behavioural functions within the brain.[1] They receive inputs from dopaminergic, serotonergic, noradrenergic, and cholinergic cell groups that modulate information processing.[2] Frontostriatal circuits are part of the executive functions. Executive functions include the following: selection and perception of important information, manipulation of information in working memory, planning and organization, behavioral control, adaptation to changes, and decision making.[3] These circuits are involved in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease as well as neuropsychiatric disorders including schizophrenia, depression, obsessive compulsive disorder (OCD), and in neurodevelopmental disorder such as attention-deficit hyperactivity disorder (ADHD).[3][4][5]