Geranylgeranyltransferase type 1
Macromolecular complex found in Homo sapiens / From Wikipedia, the free encyclopedia
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Geranylgeranyltransferase may be used to refer to either Geranylgeranyltransferase type 1 or Rab geranylgeranyltransferase
Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.[1]
Quick Facts protein geranylgeranyltransferase type I, Identifiers ...
protein geranylgeranyltransferase type I | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.59 | ||||||||
CAS no. | 135371-29-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts GGTase 1 α-subunit (farnesyltransferase, CAAX box), Identifiers ...
GGTase 1 α-subunit (farnesyltransferase, CAAX box) | |||||||
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Identifiers | |||||||
Symbol | FNTA | ||||||
NCBI gene | 2339 | ||||||
HGNC | 3782 | ||||||
OMIM | 134635 | ||||||
PDB | 1S64 | ||||||
RefSeq | NM_002027 | ||||||
UniProt | P49354 | ||||||
Other data | |||||||
EC number | 2.5.1.59 | ||||||
Locus | Chr. 8 p11.21 | ||||||
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Quick Facts GGTase 1 β-subunit (protein geranylgeranyl- transferase type I, β subunit), Identifiers ...
GGTase 1 β-subunit (protein geranylgeranyl- transferase type I, β subunit) | |||||||
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Identifiers | |||||||
Symbol | PGGT1B | ||||||
NCBI gene | 5229 | ||||||
HGNC | 8895 | ||||||
OMIM | 602031 | ||||||
PDB | 1S64 | ||||||
RefSeq | NM_005023 | ||||||
UniProt | P53609 | ||||||
Other data | |||||||
EC number | 2.5.1.59 | ||||||
Locus | Chr. 5 q23.1 | ||||||
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