Glutamate carboxypeptidase II
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TAH molecule, also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene.[5] Human GCPII contains 750 amino acids and weighs approximately 84 kDa.[6]
FOLH1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, folate hydrolase (prostate-specific membrane antigen) 1, folate hydrolase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600934; MGI: 1858193; HomoloGene: 136782; GeneCards: FOLH1; OMA:FOLH1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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TAH molecule | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.17.21 | ||||||||
CAS no. | 111070-04-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right.[7][8]
Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All refer to the same protein glutamate carboxypeptidase II.