Glutethimide
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Glutethimide is a hypnotic sedative that was introduced by Ciba[3] in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similar withdrawal symptoms. Doriden was the brand-name version. Current production levels in the United States (the annual quota for manufacturing imposed by the DEA has been three grams, enough for six Doriden tablets, for a number of years) point to its use only in small-scale research. Manufacturing of the drug was discontinued in the US in 1993 and discontinued in several eastern European countries in 2006.
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Trade names | Doriden, Elrodorm, Noxyron, others |
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Dependence liability | Moderate - high |
Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | Variable (Tmax = 1–6 hours)[2] |
Protein binding | ~50% |
Metabolism | Extensive hepatic |
Elimination half-life | 8–12 hours |
Excretion | Renal |
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ECHA InfoCard | 100.000.921 |
Chemical and physical data | |
Formula | C13H15NO2 |
Molar mass | 217.268 g·mol−1 |
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Melting point | 84 °C (183 °F) |
Solubility in water | 999 mg/L (30 °C/86 °F) mg/mL (20 °C) |
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