Guanylate kinase
Enzyme / From Wikipedia, the free encyclopedia
In enzymology, a guanylate kinase (EC 2.7.4.8) is an enzyme that catalyzes the chemical reaction
guanylate kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.4.8 | ||||||||
CAS no. | 9026-59-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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guanylate kinase | |||||||||||
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Identifiers | |||||||||||
Symbol | Guanylate_kin | ||||||||||
Pfam | PF00625 | ||||||||||
InterPro | IPR008144 | ||||||||||
PROSITE | PDOC00670 | ||||||||||
SCOP2 | 1gky / SCOPe / SUPFAM | ||||||||||
CDD | cd00071 | ||||||||||
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Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. This enzyme participates in purine metabolism.
Guanylate kinase catalyzes the ATP-dependent phosphorylation of GMP into GDP.[1] It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.[2][3][4] Systems biology analyses carried out by the team of Andreas Dräger also identified a pivotal role of this enzyme in the replication of SARS-CoV-2 within the human airways.[5][6][7]