Hydroxybupropion
Group of stereoisomers / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Hydroxybupropion?
Summarize this article for a 10 year old
Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion.[1] It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism.[1] With oral bupropion treatment, hydroxybupropion is present in plasma at area under the curve concentrations that are as many as 16–20 times greater than those of bupropion itself,[1][2] demonstrating extensive conversion of bupropion into hydroxybupropion in humans.[1] As such, hydroxybupropion is likely to play a very important role in the effects of oral bupropion, which could accurately be thought of as functioning largely as a prodrug to hydroxybupropion.[1] Other metabolites of bupropion besides hydroxybupropion include threohydrobupropion and erythrohydrobupropion.[3][4]
Clinical data | |
---|---|
Other names | BW 306U; 6-Hydroxybupropion |
ATC code |
|
Pharmacokinetic data | |
Elimination half-life | 15–25 hours |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C13H18ClNO2 |
Molar mass | 255.74 g·mol−1 |
3D model (JSmol) | |
| |
|