Iobenguane
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Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical.[3] It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used in nuclear medicinal diagnostic and therapy techniques as well as in neuroendocrine chemotherapy treatments.
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Trade names | Adreview, Azedra |
Other names | meta-iodobenzylguanidine mIBG, MIBG |
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Routes of administration | Intravenous |
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Formula | C8H10IN3 |
Molar mass | 275.093 g·mol−1 |
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It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as pheochromocytomas and neuroblastomas.[4] With iodine-131 it can also be used to treat tumor cells that take up and metabolize norepinephrine.