Isocitrate lyase
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Isocitrate lyase (EC 4.1.3.1), or ICL, is an enzyme in the glyoxylate cycle that catalyzes the cleavage of isocitrate to succinate and glyoxylate.[2][3] Together with malate synthase, it bypasses the two decarboxylation steps of the tricarboxylic acid cycle (TCA cycle) and is used by bacteria, fungi, and plants.[4]
Quick Facts Identifiers, EC no. ...
Isocitrate Lyase | |||||||||
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Identifiers | |||||||||
EC no. | 4.1.3.1 | ||||||||
CAS no. | 9045-78-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
Isocitrate lyase family | |||||||||
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Identifiers | |||||||||
Symbol | ICL | ||||||||
Pfam | PF00463 | ||||||||
InterPro | IPR000918 | ||||||||
PROSITE | PDOC00145 | ||||||||
SCOP2 | 1f8m / SCOPe / SUPFAM | ||||||||
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The systematic name of this enzyme class is isocitrate glyoxylate-lyase (succinate-forming). Other names in common use include isocitrase, isocitritase, isocitratase, threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.