KLF4
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors.[5][6][7] KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer.[8] It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2.[6] It has two nuclear localization sequences that signals it to localize to the nucleus.[9] In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).
In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene.[10] The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.[11] KLF4 was first identified in 1996.[12]