Labetalol
Medication used to treat high blood pressure / From Wikipedia, the free encyclopedia
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Labetalol is a medication used to treat high blood pressure and in long term management of angina.[1][2] This includes essential hypertension, hypertensive emergencies, and hypertension of pregnancy.[2] In essential hypertension it is generally less preferred than a number of other blood pressure medications.[1] It can be given by mouth or by injection into a vein.[1]
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Pronunciation | /ləˈbɛtəlɔːl/ |
Trade names | Normodyne, Trandate, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a685034 |
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Routes of administration | By mouth, intravenous |
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Bioavailability | 25% |
Protein binding | 50% |
Metabolism | Liver pass metabolism, |
Elimination half-life | Tablet: 6–8 hours; IV: 5.5 hours |
Excretion | Excreted in urine, not removed by hemodialysis |
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ECHA InfoCard | 100.048.401 |
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Formula | C19H24N2O3 |
Molar mass | 328.412 g·mol−1 |
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Chirality | Racemic mixture |
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Common side effects include low blood pressure with standing, dizziness, feeling tired, and nausea.[1] Serious side effects may include low blood pressure, liver problems, heart failure, and bronchospasm.[1] Use appears safe in the latter part of pregnancy and it is not expected to cause problems during breastfeeding.[2][3] It works by blocking the activation of β- and α-adrenergic receptors.[1]
Labetalol was patented in 1966 and came into medical use in 1977.[4] It is available as a generic medication.[2] In 2021, it was the 213th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[5][6]