Leuprorelin
Manufactured (artificial) injectable hormone / From Wikipedia, the free encyclopedia
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Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, as part of transgender hormone therapy, for early puberty, or to perform chemical castration of violent sex offenders.[10][11][12] It is given by injection into a muscle or under the skin.[10]
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Trade names | Lupron, Eligard, Lucrin, Lupaneta, others |
Other names | leuprolide, leuprolidine, A-43818, Abbott-43818, DC-2-269, TAP-144 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a685040 |
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Routes of administration | implant, subcutaneous, intramuscular |
Drug class | GnRH analogue; GnRH agonist; Antigonadotropin |
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Elimination half-life | 3 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.161.466 |
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Formula | C59H84N16O12 |
Molar mass | 1209.421 g·mol−1 |
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Leuprorelin is in the gonadotropin-releasing hormone (GnRH) analogue family of medications.[10] It works by decreasing gonadotropins and therefore decreasing testosterone and estradiol.[10] Common side effects include hot flashes, unstable mood, trouble sleeping, headaches, and pain at the site of injection.[10] Other side effects may include high blood sugar, allergic reactions, and problems with the pituitary gland.[10] Use during pregnancy may harm foetal development.[10]
Leuprorelin was patented in 1973 and approved for medical use in the United States in 1985.[10][13] It is on the World Health Organization's List of Essential Medicines.[11] It is sold under the brand name Lupron among others.[10]