Locked nucleic acid
Biological molecule / From Wikipedia, the free encyclopedia
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A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA),[1] and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. The bridge "locks" the ribose in the 3'-endo (North) conformation, which is often found in the A-form duplexes. This structure provides for increased stability against enzymatic degradation.[2][3][4][5] LNA also offers improved specificity and affinity in base-pairing as a monomer or a constituent of an oligonucleotide.[6] LNA nucleotides can be mixed with DNA or RNA residues in a oligonucleotide.