Lofexidine
Medication used for opioid withdrawal / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Lofexidine?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
Lofexidine, sold under the brand name Lucemyra among others,[1] is a medication historically used to treat high blood pressure; today, it is more commonly used to help with the physical symptoms of opioid withdrawal.[2] It is taken by mouth.[3] It is an α2A adrenergic receptor agonist.[3] It was approved for use by the Food and Drug Administration in the United States in 2018.[3]
Quick Facts Clinical data, Trade names ...
Clinical data | |
---|---|
Trade names | Britlofex, Lucemyra, Kai Er Ding, others |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth (tablets) |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | >90% |
Protein binding | 80–90% |
Metabolism | Liver (glucuronidation) |
Elimination half-life | 11 hours |
Excretion | Kidney |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C11H12Cl2N2O |
Molar mass | 259.13 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
| |
| |
NY (what is this?) (verify) |
Close
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[4]