Measles
Viral disease affecting humans / From Wikipedia, the free encyclopedia
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Measles is a highly contagious, vaccine-preventable infectious disease caused by measles virus.[3][5][11][12] Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days.[7][8] Initial symptoms typically include fever, often greater than 40 °C (104 °F), cough, runny nose, and inflamed eyes.[3][4] Small white spots known as Koplik's spots may form inside the mouth two or three days after the start of symptoms.[4] A red, flat rash which usually starts on the face and then spreads to the rest of the body typically begins three to five days after the start of symptoms.[4] Common complications include diarrhea (in 8% of cases), middle ear infection (7%), and pneumonia (6%).[5] These occur in part due to measles-induced immunosuppression.[6] Less commonly seizures, blindness, or inflammation of the brain may occur.[5][7] Other names include morbilli, rubeola, red measles, and English measles.[1][2] Both rubella, also known as German measles, and roseola are different diseases caused by unrelated viruses.[13]
Measles | |
---|---|
Other names | Morbilli, rubeola, red measles, English measles[1][2] |
A child showing a day-four measles rash | |
Specialty | Infectious disease |
Symptoms | Fever, cough, runny nose, inflamed eyes, rash[3][4] |
Complications | Pneumonia, seizures, encephalitis, subacute sclerosing panencephalitis, immunosuppression, hearing loss, blindness[5][6] |
Usual onset | 10–12 days after exposure[7][8] |
Duration | 7–10 days[7][8] |
Causes | Measles virus[3] |
Prevention | Measles vaccine[7] |
Treatment | Supportive care[7] |
Frequency | 20 million per year[3] |
Deaths | 140,000+ (2018)[9][10] |
Measles is an airborne disease which spreads easily from one person to the next through the coughs and sneezes of infected people.[7] It may also be spread through direct contact with mouth or nasal secretions.[14] It is extremely contagious: nine out of ten people who are not immune and share living space with an infected person will be infected.[5] Furthermore, measles's reproductive number estimates vary beyond the frequently cited range of 12 to 18.[15] The NIH quote this 2017 paper saying: "[a] review in 2017 identified feasible measles R0 values of 3.7–203.3".[16] People are infectious to others from four days before to four days after the start of the rash.[5] While often regarded as a childhood illness, it can affect people of any age.[17] Most people do not get the disease more than once.[7] Testing for the measles virus in suspected cases is important for public health efforts.[5] Measles is not known to occur in other animals.[14]
Once a person has become infected, no specific treatment is available,[14] although supportive care may improve outcomes.[7] Such care may include oral rehydration solution (slightly sweet and salty fluids), healthy food, and medications to control the fever.[7][8] Antibiotics should be prescribed if secondary bacterial infections such as ear infections or pneumonia occur.[7][14] Vitamin A supplementation is also recommended for children.[14] Among cases reported in the U.S. between 1985 and 1992, death occurred in only 0.2% of cases,[5] but may be up to 10% in people with malnutrition.[7] Most of those who die from the infection are less than five years old.[14]
The measles vaccine is effective at preventing the disease, is exceptionally safe, and is often delivered in combination with other vaccines.[7][18] Vaccination resulted in an 80% decrease in deaths from measles between 2000 and 2017, with about 85% of children worldwide having received their first dose as of 2017.[14] Measles affects about 20 million people a year,[3] primarily in the developing areas of Africa and Asia.[7] It is one of the leading vaccine-preventable disease causes of death.[19][20] In 1980, 2.6 million people died from measles,[7] and in 1990, 545,000 died due to the disease; by 2014, global vaccination programs had reduced the number of deaths from measles to 73,000.[21][22] Despite these trends, rates of disease and deaths increased from 2017 to 2019 due to a decrease in immunization.[23][24][25]