Myelin protein zero (P0, MPZ) is a single membrane glycoprotein[5] which in humans is encoded by the MPZ gene. P0 is a major structural component of the myelin sheath in the peripheral nervous system (PNS).[6] Myelin protein zero is expressed by Schwann cells and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS.[6] Mutations in myelin protein zero can cause myelin deficiency and are associated with neuropathies like Charcot–Marie–Tooth disease and Dejerine–Sottas disease.[7]
Quick Facts MPZ, Available structures ...
MPZ |
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Identifiers |
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Aliases | MPZ, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0, myelin protein zero, CHN2 |
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External IDs | OMIM: 159440 MGI: 103177 HomoloGene: 445 GeneCards: MPZ |
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Wikidata |
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