NAPQI
Toxic byproduct of acetaminophen / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about NAPQI?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen).[1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.
Quick Facts Clinical data, Other names ...
Clinical data | |
---|---|
Other names | N-Acetyl-p-benzoquinone imine; N-Acetylimidoquinone |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider |
|
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.168.312 |
Chemical and physical data | |
Formula | C8H7NO2 |
Molar mass | 149.149 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
Close
However, under some conditions in which NAPQI is not effectively detoxified (usually in the case of paracetamol overdose), it causes severe damage to the liver. This becomes apparent 3–4 days after ingestion and may result in death from fulminant liver failure several days after the overdose.