Nebivolol
Chemical compound / From Wikipedia, the free encyclopedia
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Nebivolol is a beta blocker used to treat high blood pressure and heart failure.[5] As with other β-blockers, it is generally a less preferred treatment for high blood pressure.[6] It may be used by itself or with other blood pressure medication.[6] It is taken by mouth.[6]
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Trade names | Nebilet, Bystolic, others |
Other names | Narbivolol, Nebivolol, Nebivololum[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608029 |
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Routes of administration | By mouth |
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Protein binding | 98% |
Metabolism | Liver (CYP2D6-mediated) |
Elimination half-life | 12-19 hours[2][3][4] |
Excretion | Kidney and fecal |
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Formula | C22H25F2NO4 |
Molar mass | 405.442 g·mol−1 |
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Common side effects include dizziness, feeling tired, nausea, and headaches.[6] Serious side effects may include heart failure and bronchospasm.[6] Its use in pregnancy and breastfeeding is not recommended.[5][7] It works by blocking β1-adrenergic receptors in the heart and dilating blood vessels.[6][8]
Nebivolol was patented in 1983 and came into medical use in 1997.[9] It is available as a generic medication in the United Kingdom.[5] In 2021, it was the 244th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[10][11]