Neuropeptide S
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brain areas.[5][6][7] NPS binds specifically to a G protein-coupled receptor, NPSR.[8][9] Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear.[10][11][12][13][14][15][16] It has also been shown to significantly enhance dopamine activity in the mesolimbic pathway,[16] and inhibits motility and increases permeability in neurocrine fashion acting through NO in the myenteric plexus in rats and humans.[17]
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Aliases | NPS, neuropeptide S | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609513 MGI: 3642232 HomoloGene: 106066 GeneCards: NPS | ||||||||||||||||||||||||||||||||||||||||||||||||||
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