Norepinephrine–dopamine reuptake inhibitor
Drug that inhibits the reuptake of norepinephrine and dopamine / From Wikipedia, the free encyclopedia
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A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug used for the treatment of clinical depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, and the management of Parkinson's disease. The drug acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.[1] This in turn leads to increased extracellular concentrations of both norepinephrine and dopamine and, therefore, an increase in adrenergic and dopaminergic neurotransmission.[1]
A closely related type of drug is a norepinephrine–dopamine releasing agent (NDRA).