P2Y receptor
Subclass of purinergic P2 receptors / From Wikipedia, the free encyclopedia
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P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.[1]
P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation,[2] blood clotting,[3] and immune response.[4] Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.[3]