Parecoxib
Type of nonsteroidal anti-inflammatory drug / From Wikipedia, the free encyclopedia
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For the "dynastat" type of hybrid airship, see Hybrid airship.
Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved in the European Union for short term perioperative pain control.
Quick Facts Clinical data, AHFS/Drugs.com ...
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Routes of administration | Intravenous, intramuscular |
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Bioavailability | 100% |
Protein binding | 98% |
Metabolism | Liver to valdecoxib and propionic acid CYP extensively involved (mainly CYP3A4 and 2C9) |
Elimination half-life | 22 minutes (parecoxib) 8 hours (valdecoxib) |
Excretion | Kidney (70%, metabolites) |
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ECHA InfoCard | 100.230.078 |
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Formula | C19H18N2O4S |
Molar mass | 370.42 g·mol−1 |
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It was patented in 1996 and approved for medical use in 2002.[3]