Paricalcitol
Chemical compound / From Wikipedia, the free encyclopedia
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Paricalcitol (chemically it is 19-nor-1,25-(OH)2-vitamin D2. Marketed by Abbott Laboratories under the trade name Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic kidney failure. It is an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2 (ergocalciferol).
Quick Facts Clinical data, Trade names ...
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Trade names | Zemplar |
Other names | (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R,5S)-6-hydroxy-5,6-dimethyl-3E-hepten-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-cyclohexane-1,3-diol |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682335 |
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Routes of administration | Oral, Intravenous |
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Bioavailability | 72%[1] |
Protein binding | 99.8%[1] |
Metabolism | Hepatic[1] |
Elimination half-life | 14-20 hours[1] |
Excretion | Faeces (74%), urine (16%)[1] |
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ECHA InfoCard | 100.184.862 |
Chemical and physical data | |
Formula | C27H44O3 |
Molar mass | 416.646 g·mol−1 |
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It was patented in 1989 and approved for medical use in 1998.[2]