Pseudoephedrine
Pharmaceutical drug / From Wikipedia, the free encyclopedia
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Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant,[3] as a stimulant, or as a wakefulness-promoting agent[4] in higher doses.[5]
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Pronunciation | /ˌsuːdoʊ.ɪˈfɛdrɪn, -ˈɛfɪdriːn/ |
Trade names | Afrinol, Sudafed, Sinutab, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682619 |
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Routes of administration | By mouth |
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Bioavailability | ~100%[2] |
Metabolism | 10–30% liver |
Elimination half-life | 4.3–8 hours[2] |
Excretion | 43–96% kidney[2] |
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ECHA InfoCard | 100.001.835 |
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Formula | C10H15NO |
Molar mass | 165.236 g·mol−1 |
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It was first characterized in 1889 by the German chemists Ladenburg and Oelschlägel, who used a sample that had been isolated from Ephedra vulgaris by the Merck pharmaceutical corporation of Darmstadt, Germany.[6] The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in over-the-counter preparations, either as a single ingredient or (more commonly) in a fixed-dose combination with one or more additional active ingredients such as antihistamines, guaifenesin, dextromethorphan, paracetamol (acetaminophen), or an NSAID (such as aspirin or ibuprofen).