SOCS3
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Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene.[5][6] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
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SOCS3 is a conserved gene, found in across the animal kingdom, including Drosophila,[7] chickens,[8] and crocodiles.[9]