Sarilumab
Human monoclonal antibody medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Sarilumab?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
Sarilumab, sold under the brand name Kevzara, is a human monoclonal antibody medication against the interleukin-6 receptor.[4] Regeneron Pharmaceuticals and Sanofi developed the drug for the treatment of rheumatoid arthritis (RA), for which it received US FDA approval on 22 May 2017 and European Medicines Agency approval on 23 June 2017.[5]
Parts of this article (those related to lack of effectiveness against the Omicron variant) need to be updated. (January 2022) |
Quick Facts Monoclonal antibody, Type ...
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Human |
Target | IL-6R |
Clinical data | |
Trade names | Kevzara |
AHFS/Drugs.com | Monograph |
MedlinePlus | a617032 |
License data | |
Routes of administration | Subcutaneous |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 80% |
Metabolism | likely proteases |
Elimination half-life | 21 days (steady-state, estimated) |
Identifiers | |
CAS Number | |
ChemSpider |
|
UNII | |
KEGG |
|
Chemical and physical data | |
Formula | C6388H9918N1718O1998S44 |
Molar mass | 144164.28 g·mol−1 |
NY (what is this?) (verify) |
Close
Development in ankylosing spondylitis has been suspended after the drug failed to show clinical benefit over methotrexate in a phase II trial.[6]