Sevoflurane
Inhalational anaesthetic / From Wikipedia, the free encyclopedia
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Sevoflurane, sold under the brand name Sevorane, among others, is a sweet-smelling, nonflammable, highly fluorinated methyl isopropyl ether used as an inhalational anaesthetic for induction and maintenance of general anesthesia. After desflurane, it is the volatile anesthetic with the fastest onset.[2] While its offset may be faster than agents other than desflurane in a few circumstances, its offset is more often similar to that of the much older agent isoflurane. While sevoflurane is only half as soluble as isoflurane in blood, the tissue blood partition coefficients of isoflurane and sevoflurane are quite similar. For example, in the muscle group: isoflurane 2.62 vs. sevoflurane 2.57. In the fat group: isoflurane 52 vs. sevoflurane 50. As a result, the longer the case, the more similar will be the emergence times for sevoflurane and isoflurane.[3][4][5]
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Trade names | Sojourn, Ultane, Sevorane, others |
AHFS/Drugs.com | Consumer Drug Information |
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Routes of administration | Inhaled |
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Metabolism | Liver by CYP2E1 |
Metabolites | Hexafluoroisopropanol |
Elimination half-life | 15–23 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.171.146 |
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Formula | C4H3F7O |
Molar mass | 200.056 g·mol−1 |
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Density | 1.53 g/cm3 |
Boiling point | 58.5 °C (137.3 °F) |
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It is on the World Health Organization's List of Essential Medicines.[6]