Signet ring cell
Cell with a large vacuole / From Wikipedia, the free encyclopedia
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In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer,[1] but can arise from any number of tissues including the prostate,[2] bladder, gallbladder,[3] breast, colon,[4] ovarian stroma and testis.[5]