TMPRSS2
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.[5][6][7] It belongs to the TMPRSS family of proteins, whose members are transmembrane proteins which have a serine protease activity.[8] The TMPRSS2 protein is found in high concentration in the cell membranes of epithelial cells of the lung and of the prostate, but also in the heart, liver and gastrointestinal tract.[8]
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TMPRSS2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602060 MGI: 1354381 HomoloGene: 4136 GeneCards: TMPRSS2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Mutations of the TMPRSS2 gene are often involved in prostate cancer. Several viruses, including SARS-CoV-2, use the protease activity of the TMPRSS2 protein in the process of entering cells.[8]