Tafenoquine
Antimalarial drug / From Wikipedia, the free encyclopedia
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Tafenoquine, sold under the brand name Krintafel among others, is a medication used to prevent and to treat malaria.[3] With respect to acute malaria, it is used together with other medications to prevent relapse by Plasmodium vivax.[3] It may be used to prevent all types of malaria.[3] It is taken by mouth.[4]
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Pronunciation | ta fen' oh kwin |
Trade names | Krintafel, Arakoda, others |
Other names | Etaquine,[1] WR 238605,[1] SB-252263 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a618050 |
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Routes of administration | By mouth |
Drug class | Antimalarial |
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Formula | C24H28F3N3O3 |
Molar mass | 463.501 g·mol−1 |
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Common side effects include vomiting, headache, and dizziness.[4] Other side effects may include methemoglobinemia, trouble sleeping, and anaphylaxis.[4] In people with G6PD deficiency, red blood cell breakdown may occur.[4] Use in pregnancy is not recommended.[4] Tafenoquine is in the 8-aminoquinoline family of medications.[3] How it works is unclear but it is effective both in the liver and bloodstream.[4][3] A possible mechanism of action and other novel perspectives have been published.[5]
Tafenoquine was approved for medical use in Australia and in the United States in 2018.[3][6] Tafenoquine is related to primaquine.[7]