Trichlormethiazide
Chemical compound / From Wikipedia, the free encyclopedia
Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1] In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.[2]
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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Routes of administration | Oral (capsules, tablets, oral solution) |
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Bioavailability | Variably absorbed from GI tract |
Excretion | Primarily excreted unchanged in urine |
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ECHA InfoCard | 100.004.654 |
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Formula | C8H8Cl3N3O4S2 |
Molar mass | 380.64 g·mol−1 |
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As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl− ion reabsorption from the distal tubules of the kidneys.[1] In addition, trichlormethiazide increases the excretion of potassium.[1]