User:Hopur52009
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The development of nicotinic acetylcholine receptor agonists began in the early 1990’s after the discovery of nicotine’s positive effects on animal memory.[1][2] The development of nicotinic acetylcholine receptor agonists has come a long way since then. The nicotinic acetylcholine receptor agonist are gaining increasing attention as drug candidates for multiple central nervous system disorders such as Alzheimer's disease, schizophrenia, attention-deficit hyperactivity disorder (ADHD) and nicotine addiction.[3][4] Nicotinic acetylcholine receptors are receptors found in the central nervous system, the peripheral nervous systems and skeletal muscles. They are ligand-gated ion channels with binding sites for acetylcholine as well as other agonists. When agonists bind to a receptor it stabilizes the open state of the ion channel allowing influx of cations. [5]
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In 2009 there where at least five drugs on the market that effect the nicotinic acetylcholine receptors.