Zeranol
Chemical compound / From Wikipedia, the free encyclopedia
Zeranol (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name) (brand names Frideron, Ralabol, Ralgro, Ralone, Zerano; developmental code names MK-188, P-1496), or zearanol, also known as α-zearalanol or simply zearalanol, is a synthetic nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in fungi in the Fusarium genus and is used mainly as an anabolic agent in veterinary medicine.[1][2][3]
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Trade names | Frideron, Ralabol, Ralgro, Ralone, Zerano |
Other names | Zearanol; α-Zearalanol; Zearalanol; MK-188; P-1496 |
Routes of administration | By mouth |
Drug class | Nonsteroidal estrogen |
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ECHA InfoCard | 100.043.411 |
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Formula | C18H26O5 |
Molar mass | 322.401 g·mol−1 |
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Zeranol is approved for use as a growth promoter in livestock, including beef cattle, under the brand name Ralgro (by Merck Animal Health) in the United States.[4] In Canada, it is approved for use in beef cattle only.[5] Its application is not approved for use in the European Union. However, it is marketed under the brand name Ralone in Spain.[2]
Although zeranol may increase cancer cell proliferation in already existing breast cancer,[6] dietary exposure from the use of zeranol-containing implants in cattle is insignificant.[7] Zeranol may be found as a contaminant in fungus-infected crops. It is 3 to 4 times more potent as an estrogen than the related compound zearalenone.[8] It is a metabolite of zearalenone.[9]