Zollinger–Ellison syndrome
Condition in which tumours stimulate excessive gastric acid production / From Wikipedia, the free encyclopedia
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Zollinger–Ellison syndrome (Z-E syndrome) is rare disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea.
Zollinger–Ellison syndrome | |
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Other names | gastrinoma, pancreatic ulcerogenic tumor syndrome, ZES, Z-E syndrome[1] |
Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger–Ellison syndrome | |
Specialty | Endocrinology |
Causes | Gastrinoma |
The syndrome is caused by a gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin.[2] Too much gastrin in the blood (hypergastrinemia) results in the overproduction of gastric acid by parietal cells in the stomach. Gastrinomas most commonly arise in the duodenum, pancreas or stomach.[citation needed]
In 75% of cases Zollinger–Ellison syndrome occurs sporadically, while in 25% of cases it occurs as part of an autosomal dominant syndrome called multiple endocrine neoplasia type 1 (MEN 1).[3]