4-Methoxyestriol
Chemical compound / From Wikipedia, the free encyclopedia
4-Methoxyestriol (4-MeO-E3) is an endogenous estrogen metabolite.[1][2][3][4] It is the 4-methyl ether of 4-hydroxyestriol and a metabolite of estriol and 4-hydroxyestriol.[1][2][3] 4-Methoxyestriol has very low affinities for the estrogen receptors.[4] Its relative binding affinities (RBAs) for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) are both about 1% of those of estradiol.[4] For comparison, estriol had RBAs of 11% and 35%, respectively.[4]
Quick Facts Names, Identifiers ...
Names | |
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IUPAC name
4-Methoxyestra-1,3,5(10)-triene-3,16α,17β-triol | |
Systematic IUPAC name
(1R,2R,3aS,3bR,9bS,11aS)-6-Methoxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,2,7-triol | |
Other names
4-MeO-E3 | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
PubChem CID |
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Properties | |
C19H26O4 | |
Molar mass | 318.413 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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