User:Mr. Ibrahem/Desvenlafaxine
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Clinical data | |
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Trade names | Pristiq, Desfax, Ellefore, others |
Other names | O-desmethylvenlafaxine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608022 |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
Drug class | Serotonin-norepinephrine reuptake inhibitor[1] |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | 80% |
Protein binding | Low (30%) |
Metabolism | CYP3A4, (CYP2D6 is not involved) |
Elimination half-life | 11 h |
Excretion | 45% excreted unchanged in urine |
Identifiers | |
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Chemical and physical data | |
Formula | C16H25NO2 |
Molar mass | 263.381 g·mol−1 |
3D model (JSmol) | |
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NY (what is this?) (verify) |
Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat major depressive disorder.[1] It is recommended that the need for further treatment be occasionally reassessed.[1] It appears less effective than its parent compound venlafaxine.[2] It is taken by mouth.[1]
Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure.[1] A withdrawal syndrome may occur if the dose is rapidly decreased.[1] It is unclear if use during pregnancy or breastfeeding is safe.[3] It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.[1]
Desvenlafaxine was approved for medical use in the United States in 2008.[1] Use in Europe was declined in 2009.[2] In the United States the wholesale cost is about 25.20 USD per month.[4] In 2017, it was the 235th most commonly prescribed medication in the United States, with more than two million prescriptions.[5][6]